0
<-- nev left start -->

Xylometazoline Hydrochloride

Xylometazoline Hydrochloride
Xylometazoline Hydrochloride
Price And Quantity
  • Kilograms/Kilograms
  • 500
  • Kilograms/Kilograms
Product Specifications
  • Freely soluble in Water, in alcohol and in methanol
  • C16H24N2.HCl
  • 280.84 Grams (g)
  • Not more than 0.5%
  • C16H24N2.HCL
  • Room Temperature
  • 5.0-6.6
  • 1218-35-5
  • Vasoconstrictor, used as a nasal decongestant.
  • Powder
    Product Description

    Our firm is betrothed in offering supreme quality Xylometazoline HCl to our esteemed clients. It helps to decrease nasal congestion and is demanded in pharmaceutical industry to make medicines for treatment of high blood pressure. This chemical is formulated at our well equipped formulating unit under the stern guidance our dexterous professionals. The offered Xylometazoline HCl is available in a variety of packaging options to meet the diverse needs of our clients. This extract is strictly tested by our team of quality analysts prior to dispatch from our end.

    Features:

    • High effectiveness

    • Longer shelf life

    • Purity

    • Accurate composition

      Specifications:

    • Molecular Weight : 280.84
    • Molecular Formula : C16H24N2.HCl

    Grades

    IP

    BP/EP

    USP

    Description

    A White or almost white, crystalline powder; odorless or almost odorless.

    White to off-white, odorless crystalline powder

    White to off-white, odorless crystalline powder

    Solubility

    Freely soluble in Water, in alcohol and in methanol. Practically insoluble in ether

    Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether

    Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether

    Identification

    a) By IR (KBr)
    IR spectrum of sample recorded as KBr should exhibit maxima and minima at the same wavelengths as that of the similar preparation of IR spectra of Xylometazoline Hydrochloride working standard.
    a) By IR
    IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS.
    a) By IR
    IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS.
    b) by UV
    An absorbance should be maximum at about 265 nm and minimum at about 257 nm with two inflections at about 270 nm and 275 nm.
    Absorbance at about 265 nm, about 0.5
    b) by TLC
    The principle spot obtained in test solution is similar in position and size to the principle spot in the chromatogram obtained with Xylometazoline Hydrochloride WS.
    b) By TLC
    The size ,intensity and Rf value of principal spot obtained from The test solution correspond to those of the principal spot obtained from the Xylometazoline Hydrochloride WS-solution.
    c) By chemical test
    A violet color should produce.
    c) Melting Point
    Melts at 300oC with decomposition
    c) Melting Point
    Melts above 300oC with decomposition
    d) Test for Chloride
    A curdy white precipitate should form, which settles in the test tube, indicating presence of chloride ions.

    -

    -

    pH (5.0 % w/v solution in water)

    Between 5.0 to 6.6

    -

    Between 5.0 & 6.6

    Appearance of solution (5.0% in water)


    5.0 % solution in water is clear


    Acidity/Alkalinity


    Not more than 0.2 ml 0.01 M NaOH is required.


    N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide by TLC

    Any spot corresponding to N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide in the chromatogram obtained with the test solution should not more intense than the spot in the chromatogram obtained with the reference solution (0.5%)

    -


    Related substances
    (%, by HPLC)
    Xylometazoline impurity A
    Any other impurity
    Total impurities
    (%, by HPLC)

    Not more than 0.2
    Not more than 0.1
    Not more than 0.5

    (by TLC)

    Not more than 0.2 %

    Not more than 0.2 %


    Iron (ppm)

    Not more than 50

    -


    Sulphates (ppm)

    Not more than 200

    -


    Sulphated ash (%w/w, determined on 1g)

    Not more than 0.1

    Not more than 0.1 %


    Residue on Ignition

    -

    -

    Not more than 0.1 %

    Chromatographic Purity

    -

    -

    Complies with standard

    Loss on drying (%w/w, determined on 1g at 105oC, for 4 hr.)

    Not more than 0.5


    Not more than 0.5 %


    Not more than 0.5 %

    Assay (%w/w C16H24N2HCl , on dried basis)

    (by Titrimetry)
    Not less than 99.0 and Not more than 101.0
    (by Potentiometer)
    Between 99.0 % and 101.0 %
    (by Potentiometer)
    Between 99.0 % and 101.0 %
    Residual Solvents
    (by GC, g/g)
    Methanol
    Acetone
    Isopropyl alcohol
    Tert butyl alcohol
    Ethyl acetate
    Benzene
    Methyl iso butyl ketone
    Toluene
    m-Xylene



    Not more than 3000
    Not more than 3000
    Not more than 3000
    Not more than 3000
    Not more than 3000
    Not more than 2
    Not more than 500
    Not more than 890
    Not more than 500



    Trade Information
    • Telegraphic Transfer (T/T), Letter of Credit (L/C), Cash in Advance (CID), Cash Advance (CA)
    • 200 Per Day
    • 1 Days
    • All India
    • GMP Drug Manufacturing Lic with schedule M ISO 9001:2008 ISO 22000:2018 Vegetarian Certificate Halal Certificate
    Contact Us

    Plot No. 355/2, G.I.D.C. Estate, Chitra Bhavnagar Gujarat India 91-278-2445541
    Phone :09429005558